MPGN, also known as Membrano-Proliferative Glomerulonephritis, is a kind of Glomerulone Nephritis. Here I will guide you to look at this disease.
MPGN also has other names, such as Mesangiocapillary. Nephropathy, but they all refer the same disease. MPGN is named based on the appearance of kidney biopsy under the microscope.
The symptoms of MPGN are various. Some patients have no symptoms, while some others have Nephrotic Syndrome, for example, there are symptoms with protein leakage, water retention, the swelling in face, hands, or feet, etc.
Complications of MPGN include these: 1. High blood pressure. Due to the damage to kidneys, patients may develop high blood pressure. 2. Kidney Failure. People with MPGN have the great risk of suffering Kidney Failure. 3. Protein leakage from the kidneys may lead to the swollen ankles and the high levels of cholesterol in the blood.
MPGN most commonly presents in childhood but it can occur at any age. MPGN is a type of Glomerulonephritis caused by the deposition in the kidney glomerular mesangium and basement membrane.
MPGN can be diagnosed only after the biopsy test of kidneys. There are generally two types of MPGN, they are type 1 and type 2 MPGN.
Type 1 is the most common type by far. It is characterized by the subendothelial and mesangial immune deposits in the kidneys.
Type 2 is similar to Type 1. It is also called as “dense deposit disease”. It is believed that it is associated with the alternative complement pathway.
The above are the brief introduction on MPGN. If you have any questions, you can tell us so we can help you.
