Proteinuria, the typical symptoms of chronic kidney disease, proteinuria causes of glomerular barrier function has a close relationship. Glomerular capillary consists of a three-tier structure, from inside to outside, respectively, for the endothelial cell layer, the base layer and epithelial cell layer. The cell of this three-tiered distribution of the filter pore sizes and negative charge, the barrier function of the glomerular capillary can be divided into two, namely, the mechanical barrier - the filter hole and charge barrier - negative charge.
iga nephropathy is already a common disease, and disease prevalence populations teenagers is more common, how treatment when iga nephropathy accompanied by proteinuria? proteinuria is the symptoms of kidney disease, people with iga nephropathy with proteinuria is not wonderful, we just treatment will play an effective role for the cause, following up a look.
The experts pointed out that: proteinuria is a symptom of a kidney injury, once this symptom occurs, it should be resolved as soon as possible for iga nephropathy patients with proteinuria how do is the same, we must first eliminate proteinuria.
IgA nephropathy with hematuria, with a large number of proteinuria is often ignored, and misleading treatment of renal biopsy before diagnosis. The nephrotic hospital had some IgA nephropathy patients, clinical statistics, found in the extraction of medical records in IgA nephropathy urine protein up to 3.0 ~ 4.5 g/24h, more performance for the nephrotic syndrome.
The pathogenesis of IgA nephropathy proteinuria is complex and depends on the degree of glomerular and (or) tubular injury. In the hospital extracted proteinuria in patients with IgA nephropathy, the serum creatinine, blood urea nitrogen were increased, indicating that glomerular function by varying degrees of damage; pathologically confirmed pathological grade, renal tubular interstitial fibrosis in IgA nephropathy 24h proteinuria amount, suggesting tubulointerstitial damage may be an important mechanism of proteinuria in patients with IgA nephropathy.
Clinical manifestations of proteinuria in patients with IgA nephropathy, suggesting tubulointerstitial damage, protect the kidney function is very important. Massive proteinuria as the main clinical manifestations of IgA nephropathy, although the cause can not be independent for a set of characteristic cases, but in clinical practice does have separate performance of proteinuria in IgA nephropathy medical treatment of hematuria of IgA patients with kidney disease is more difficult. Recent studies confirmed proteinuria promote the progress of IgA nephropathy. Accompanied by a large number of animal models of proteinuria, proteinuria increase of extracellular matrix proteins and TGF-β in the gene encoding the kidney protease inhibitor increased expression; the degree of proteinuria and renal interstitial inflammation, and monocyte-macrophage cell infiltration .
Restricted diet of protein intake may reverse the glomerular filtration and small ball and small tube mast, slow decline in glomerular filtration rate. Extracted the medical records of massive proteinuria in IgA nephropathy showed pathological damage, re-graded, renal tubular damage and proteinuria; clinical manifestations of serum creatinine, blood urea nitrogen. Prompted massive proteinuria may contribute to the progress of IgA nephropathy.
treatment of proteinuria with Iga nephropathy patients :
1 , A traditional Chinese medicine treatment of urinary protein. Penetration of the active ingredients of traditional Chinese medicine directly to the damaged glomerular, tubular, to repair, and increased glomerular filtration ability of the protein, progressive renal tubular reabsorption of protein capacity.
2, Immunosuppressive therapy, urinary protein. Chinese medicine effective active ingredient in the treatment of urinary protein is a process, iga nephropathy patients in the initial stages of treatment still need to immunosuppressant drug class with the to ensure that protein is down in the near future, so that traditional Chinese medicine to catch this opportunity to to repair the damaged kidney.
3, If necessary, be combined with hormone therapy proteinuria. All know, prices and other reasons, some patients in the initial stages of treatment of urinary protein still want to use hormone treatment of patients with iga nephropathy urinary protein with Western. It goes with the use of immunosuppressive agents is the same, all the protein in the short term stable housing, repair the kidney to the traditional Chinese medicine to provide a more comfortable time.
After a certain period of treatment, when the kidney tissue repair by traditional Chinese medicine active substances, glomerular filtration protein and tubular reabsorption of the protein's ability to rise gradually restored, proteinuria will gradually decline, and finally negative.
Got iga nephropathy is not terrible, horrible, no systematic treatment to delay the disease, delayed treatment period, so if it is found necessary to systematic treatment, can not be purely symptomatic treatment, from the pathological injury to start, Hospital Nephrology for the treatment of iga nephropathy, iga nephropathy of Chinese medicine treatment at the same time, the use of the theory of Chinese medicine and treatment methods to check the diagnosis of disease, observation analysis of disease treatment principles and methods of disease experienced repeated validation and to enrich and perfect to take different approaches to treatment differences according to the pathological findings, a leading level in the treatment of a variety of nephritis, cure many patients, the majority of renal patients at home.
iga nephropathy patients with proteinuria with treatment including:
1, Patients in the diet to ensure high-quality low-protein intake should not eat salty foods to avoid increasing the burden on the kidneys, the filtration ability of the protein further decline;
2, Prevent colds, in order to minimize the probability of induced urinary protein repeated;
3, Should not be overworked, the right amount of activity;
4, Strictly by your doctor to pay attention to every little detail of life.
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